Reactome | RAN:GTP [cytosol]

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RAN:GTP [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9616199] RAN:GTP:TNPO1 [cytosol] - Homo sapiens [Complex:R-HSA-165556] Crm1:Ran GTPase:GTP [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP - Homo sapiens [Reaction:R-NUL-9616174] RAN:GTP binds transportin associated with Nup107-160 and displaces Nup107-160 - Homo sapiens [Reaction:R-NUL-9616176] RAN:GTP binds importin beta associated with nup107-160 and displaces nup107-160 - Xenopus laevis [Reaction:R-HSA-9615945] RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 - Homo sapiens [Reaction:R-HSA-9624876] RAN:GTP recruits nuclear envelope (NE) membranes - Homo sapiens [Reaction:R-HSA-5578744] Importin-8 imports AGO2:miRNA into the nucleus - Homo sapiens
created	[InstanceEdit:180700] Matthews, L, 2006-06-02 09:25:32
dbId	180686
deleted	[Deleted:9615450] Deletion of instance: 207001
displayName	RAN:GTP [cytosol]
hasComponent	[SimpleEntity:R-ALL-29438] GTP [cytosol] [EntityWithAccessionedSequence:R-HSA-165540] RAN [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-180686] RAN:GTP [cytosol] - Mus musculus [Complex:R-RNO-180686] RAN:GTP [cytosol] - Rattus norvegicus [Complex:R-CFA-180686] RAN:GTP [cytosol] - Canis familiaris [Complex:R-BTA-180686] RAN:GTP [cytosol] - Bos taurus [Complex:R-DRE-180686] RAN:GTP [cytosol] - Danio rerio [Complex:R-XTR-180686] RAN:GTP [cytosol] - Xenopus tropicalis [Complex:R-GGA-180686] RAN:GTP [cytosol] - Gallus gallus [Complex:R-DME-180686] RAN:GTP [cytosol] - Drosophila melanogaster [Complex:R-CEL-180686] RAN:GTP [cytosol] - Caenorhabditis elegans [Complex:R-DDI-180686] RAN:GTP [cytosol] - Dictyostelium discoideum [Complex:R-SPO-180686] RAN:GTP [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-180686] RAN:GTP [cytosol] - Saccharomyces cerevisiae [Complex:R-PFA-180686] RAN:GTP [cytosol] - Plasmodium falciparum
maxDepth	2
modified	[InstanceEdit:9615965] Orlic-Milacic, Marija, 2018-08-09
name	RAN:GTP
producedByEvent	[Reaction:R-HSA-9624845] RCC1 stimulates GDP to GTP exchange on RAN - Homo sapiens [Reaction:R-HSA-165028] Release of the HIV mRNA and Crm1 from Rev in the cytoplasm - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-180686
updateTrackers	[UpdateTracker:9899445] Update Tracker - [Complex:180686] RAN:GTP [cytosol] - v66:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9899445] Update Tracker - [Complex:180686] RAN:GTP [cytosol] - v66:[modifyName]
(replacementInstances)	[Deleted:9615450] Deletion of instance: 207001
(input)	[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP [Reaction:R-NUL-9616174] RAN:GTP binds transportin associated with Nup107-160 and displaces Nup107-160 [Reaction:R-NUL-9616176] RAN:GTP binds importin beta associated with nup107-160 and displaces nup107-160 [Reaction:R-HSA-9615945] RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 [Reaction:R-HSA-9624876] RAN:GTP recruits nuclear envelope (NE) membranes [Reaction:R-HSA-5578744] Importin-8 imports AGO2:miRNA into the nucleus
(requiredInputComponent)	[Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
(output)	[Reaction:R-HSA-165028] Release of the HIV mRNA and Crm1 from Rev in the cytoplasm [Reaction:R-HSA-9624845] RCC1 stimulates GDP to GTP exchange on RAN
(hasComponent)	[Complex:R-HSA-165556] Crm1:Ran GTPase:GTP [cytosol] [Complex:R-HSA-9616199] RAN:GTP:TNPO1 [cytosol] [Complex:R-NUL-9616202] RAN:GTP:kpnb1 [cytosol] [Complex:R-HSA-9615960] RAN:GTP:KPNB1,TNPO1 [cytosol] [Complex:R-HSA-9624877] RAN:GTP:Nuclear envelope vesicles [nuclear envelope]

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