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RAN:GTP [cytosol]
Stable Identifier
R-HSA-180686
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)
RAN:GTP:Nuclear envelope vesicles [nuclear envelope] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RAN:GTP:KPNB1,TNPO1 [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RAN:GTP:Nuclear envelope vesicles [nuclear envelope] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol] (Homo sapiens)
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
RAN:GTP [cytosol] (Homo sapiens)
Participants
components
GTP [cytosol]
RAN [cytosol]
(Homo sapiens)
Participates
as an input of
Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
RAN:GTP binds transportin associated with Nup107-160 and displaces Nup107-160 (Homo sapiens)
RAN:GTP binds importin beta associated with nup107-160 and displaces nup107-160 (Xenopus laevis)
RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 (Homo sapiens)
RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)
as an output of
Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)
RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)
as a component of
Crm1:Ran GTPase:GTP [cytosol] (Homo sapiens)
RAN:GTP:TNPO1 [cytosol] (Homo sapiens)
RAN:GTP:kpnb1 [cytosol] (Xenopus laevis)
RAN:GTP:KPNB1,TNPO1 [cytosol] (Homo sapiens)
RAN:GTP:Nuclear envelope vesicles [nuclear envelope] (Homo sapiens)
Inferred To
RAN:GTP [cytosol]
(Bos taurus)
RAN:GTP [cytosol]
(Caenorhabditis elegans)
RAN:GTP [cytosol]
(Canis familiaris)
RAN:GTP [cytosol]
(Danio rerio)
RAN:GTP [cytosol]
(Dictyostelium discoideum)
RAN:GTP [cytosol]
(Drosophila melanogaster)
RAN:GTP [cytosol]
(Gallus gallus)
RAN:GTP [cytosol]
(Mus musculus)
RAN:GTP [cytosol]
(Plasmodium falciparum)
RAN:GTP [cytosol]
(Rattus norvegicus)
RAN:GTP [cytosol]
(Saccharomyces cerevisiae)
RAN:GTP [cytosol]
(Schizosaccharomyces pombe)
RAN:GTP [cytosol]
(Sus scrofa)
RAN:GTP [cytosol]
(Xenopus tropicalis)
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