Reactome | RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160

Schema > Reaction > Entries

RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 Show undefined attributes

authored	[InstanceEdit:9667932] Gerace, Larry, 2019-11-07
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9615944] Orlic-Milacic, Marija, 2018-08-09
dbId	9615945
displayName	RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160
edited	[InstanceEdit:9668537] Orlic-Milacic, Marija, 2019-11-26
eventOf	[Pathway:R-HSA-9615933] Postmitotic nuclear pore complex (NPC) reformation - Homo sapiens
inferredFrom	[Reaction:R-NUL-9616174] RAN:GTP binds transportin associated with Nup107-160 and displaces Nup107-160 - Homo sapiens [Reaction:R-NUL-9616176] RAN:GTP binds importin beta associated with nup107-160 and displaces nup107-160 - Xenopus laevis
input	[Complex:R-HSA-9615954] KPNB1,TNPO1:Nup107-160 complex [cytosol] [Complex:R-HSA-180686] RAN:GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160
output	[Complex:R-HSA-377883] Nup107-160 complex [cytosol] [Complex:R-HSA-9615960] RAN:GTP:KPNB1,TNPO1 [cytosol]
precedingEvent	[Reaction:R-HSA-9615937] TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex - Homo sapiens [Reaction:R-HSA-9624845] RCC1 stimulates GDP to GTP exchange on RAN - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9615945
summation	[Summation:9616185] Based on studies with recombinant human proteins and Xenopus...

Referrals

(hasEvent)	[Pathway:R-HSA-9615933] Postmitotic nuclear pore complex (NPC) reformation
(precedingEvent)	[NegativePrecedingEvent:9764066] Futile Cycle: RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 [NegativePrecedingEvent:9764070] Futile Cycle: RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160
(inferredTo)	[Reaction:R-NUL-9616174] RAN:GTP binds transportin associated with Nup107-160 and displaces Nup107-160 [Reaction:R-NUL-9616176] RAN:GTP binds importin beta associated with nup107-160 and displaces nup107-160

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