Reactome | ATF4 activates genes in response to endoplasmic reticulum stress

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ATF4 activates genes in response to endoplasmic reticulum stress Show undefined attributes

authored	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	380994
displayName	ATF4 activates genes in response to endoplasmic reticulum stress
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf	[Pathway:R-HSA-381042] PERK regulates gene expression - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5673196] PERK-mediated unfolded protein response
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-1791173] Expression of ATF3 - Homo sapiens [BlackBoxEvent:R-HSA-1791118] Expression of ASNS (Asparagine Synthetase) - Homo sapiens [BlackBoxEvent:R-HSA-1791056] Expression of CCL2 - Homo sapiens [BlackBoxEvent:R-HSA-1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - Homo sapiens [BlackBoxEvent:R-HSA-1791095] Expression of HERPUD - Homo sapiens [BlackBoxEvent:R-HSA-1791180] Expression of IGFBP1 - Homo sapiens [BlackBoxEvent:R-HSA-517731] Expression of IL-8 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:535558] Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK [LiteratureReference:535556] Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation [LiteratureReference:535539] Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells [LiteratureReference:535513] Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids [LiteratureReference:535562] The unfolded protein response is an important regulator of inflammatory genes in endothelial cells [LiteratureReference:535605] Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4 [LiteratureReference:535509] Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways [LiteratureReference:535560] Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	ATF4 activates genes in response to endoplasmic reticulum stress
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-380994
summation	[Summation:387099] ATF4 is a transcription factor and activates expression of I...
updateTrackers	[UpdateTracker:9775751] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v78:[updateContainedRLE] [UpdateTracker:9778661] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v68:[updateContainedRLE] [UpdateTracker:9785594] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v51:[updateContainedRLE] [UpdateTracker:9777712] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v69:[updateContainedRLE] [UpdateTracker:9777561] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v70:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9775751] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v78:[updateContainedRLE]
[UpdateTracker:9778661] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v68:[updateContainedRLE]
[UpdateTracker:9785594] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v51:[updateContainedRLE]
[UpdateTracker:9777712] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v69:[updateContainedRLE]
[UpdateTracker:9777561] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v70:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-381042] PERK regulates gene expression

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