Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein

Stable Identifier
Reaction [omitted]
Homo sapiens
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The DDIT3 (CHOP) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Bartlett et al. 1992, Carlson et al. 1993, Bruhat et al. 1997, Yoshida et al. 2000, Lee et al. 2008, Sikalidis et al. 2011). In response to amino acid starvation, transcription of DDIT3 s enhanced by ATF4 and phosphorylated ATF2 (Bruhat et al. 2000, Averous et al. 2004, Bruhat et al. 2007). In mouse, expression of Ddit3 is activated by DNA damage and by NF-Y and Atf4 in response to endoplasmic reticulum stress.

Literature References
PubMed ID Title Journal Year
10958673 ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

Mori, K, Yoshida, H, Yanagi, H, Negishi, M, Okada, T, Haze, K, Yura, T

Mol Cell Biol 2000
22802018 Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress

Tsukada, S, Yoshida, K, Takeuchi, Y, Fukuda, R, Takayanagi, S

Cell Stress Chaperones 2013
This event is regulated
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