SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)

Stable Identifier
R-HSA-177945
Type
Reaction
Species
Homo sapiens
Compartment
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Son of sevenless homolog 1 (SOS1) is the guanine nucleotide exchange factor (GEF) for rat sarcoma (RAS) protein. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L

Science 1993
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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