GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR

Stable Identifier
R-HSA-177936
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
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The tyrosine sites on SHC1 become possible binding sites for the GRB2:SOS1 complex.

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L

Science 1993
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Orthologous Events
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Sus scrofa)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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