SHC1 binds to the phosphorylated EGF receptor:ligand complex

Stable Identifier
R-HSA-177925
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SHC1 (Src homology 2 domain-containing) transforming protein can bind to either phosphorylated tyrosine 1148 (p-Y1148) and/or tyrosine 1173 (p-Y1173) sites on the EGF receptor. The N-terminal phosphotyrosine binding domain (PBD) of SHC1, also known as the phosphotyrosine interaction (PI) domain, binds to phosphorylated p-Y1148 of EGFR, which is part of the NPXpY motif. The SH2 domain of SHC1 binds to p-Y1173 of EGFR (Batzer et al. 1995, Songyang et al. 1995, Sakaguchi et al. 1998).

Literature References
PubMed ID Title Journal Year
7541030 The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif

Songyang, Z, Margolis, B, Chaudhuri, M, Shoelson, SE, Cantley, LC

J. Biol. Chem. 1995
7542744 The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

Batzer, AG, Blaikie, P, Nelson, K, Schlessinger, J, Margolis, B

Mol. Cell. Biol. 1995
9544989 Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells

Sakaguchi, K, Okabayashi, Y, Kido, Y, Kimura, S, Matsumura, Y, Inushima, K, Kasuga, M

Mol Endocrinol 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created