SHC1 binds to the phosphorylated EGF receptor:ligand complex

Stable Identifier
Reaction [binding]
Homo sapiens
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SHC1 (Src homology 2 domain-containing) transforming protein can bind to either phosphorylated tyrosine sites Y1172 (p-Y1172) i.e. Y1148 (p-Y1148) in the mature protein and/or tyrosine Y1197 (p-Y1197) i.e. Y1173 (p-Y1173) in the mature protein on the EGF receptor. The N-terminal phosphotyrosine binding domain (PBD) of SHC1, also known as the phosphotyrosine interaction (PI) domain, binds to phosphorylated p-Y1172 (i.e. p-Y1148) of EGFR, which is part of the NPXpY motif. The SH2 domain of SHC1 binds to p-Y1192 (i.e. p-Y1173) of EGFR (Batzer et al. 1995, Songyang et al. 1995, Sakaguchi et al. 1998).

Literature References
PubMed ID Title Journal Year
7542744 The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

Schlessinger, J, Batzer, AG, Blaikie, P, Nelson, K, Margolis, B

Mol. Cell. Biol. 1995
7541030 The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif

Cantley, LC, Songyang, Z, Shoelson, SE, Chaudhuri, M, Margolis, B

J. Biol. Chem. 1995
9544989 Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells

Matsumura, Y, Sakaguchi, K, Kasuga, M, Inushima, K, Kido, Y, Okabayashi, Y, Kimura, S

Mol Endocrinol 1998
Orthologous Events
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