Reactome | SHC1 binds to the phosphorylated EGF receptor:ligand complex

SHC1 binds to the phosphorylated EGF receptor:ligand complex

Stable Identifier

R-HSA-177925

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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SHC1 binds to the phosphorylated EGF receptor:ligand complex

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SHC1 (Src homology 2 domain-containing) transforming protein can bind to either phosphorylated tyrosine sites Y1172 (p-Y1172) i.e. Y1148 (p-Y1148) in the mature protein and/or tyrosine Y1197 (p-Y1197) i.e. Y1173 (p-Y1173) in the mature protein on the EGF receptor. The N-terminal phosphotyrosine binding domain (PBD) of SHC1, also known as the phosphotyrosine interaction (PI) domain, binds to phosphorylated p-Y1172 (i.e. p-Y1148) of EGFR, which is part of the NPXpY motif. The SH2 domain of SHC1 binds to p-Y1192 (i.e. p-Y1173) of EGFR (Batzer et al. 1995, Songyang et al. 1995, Sakaguchi et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
7542744	The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor Batzer, AG, Blaikie, P, Nelson, K, Schlessinger, J, Margolis, B	Mol. Cell. Biol.	1995
7541030	The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif Songyang, Z, Margolis, B, Chaudhuri, M, Shoelson, SE, Cantley, LC	J. Biol. Chem.	1995
9544989	Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells Sakaguchi, K, Okabayashi, Y, Kido, Y, Kimura, S, Matsumura, Y, Inushima, K, Kasuga, M	Mol Endocrinol	1998