Reactome | Sustained activation of SRC kinase by SHP2

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Sustained activation of SRC kinase by SHP2 Show undefined attributes

catalystActivity	[CatalystActivity:10462090] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10462092
displayName	Sustained activation of SRC kinase by SHP2
eventOf	[Pathway:R-SSC-180292] GAB1 signalosome - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-177923] Sustained activation of SRC kinase by SHP2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-SSC-180522] p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Sustained activation of SRC kinase by SHP2
output	[EntityWithAccessionedSequence:R-SSC-180499] CSK [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-SSC-180523] PXN:MyrG-SRC [plasma membrane]
precedingEvent	[Reaction:R-SSC-177926] Dephosphorylation of PAG by SHP2 - Sus scrofa [Reaction:R-SSC-177944] Activation of SHP2 through the binding to phospho-Gab1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-177923
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-180292] GAB1 signalosome
(inferredTo)	[Reaction:R-HSA-177923] Sustained activation of SRC kinase by SHP2

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