Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Glutathione synthesis and recycling
Show undefined attributes
Go to Details
authored
[InstanceEdit:156610] Jassal, B, 2004-11-30 16:21:24
created
[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
dbId
174403
displayName
Glutathione synthesis and recycling
edited
[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf
[Pathway:R-HSA-156590] Glutathione conjugation - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:21534] glutathione metabolic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-1247935] OPLAH hydrolyses OPRO to L-Glu - Homo sapiens
[Reaction:R-HSA-174367] GCL ligates L-Glu to L-Cys - Homo sapiens
[Reaction:R-HSA-1247922] GGCT transforms gGluCys to OPRO - Homo sapiens
[Reaction:R-HSA-174394] GSS:Mg2+ dimer synthesizes GSH - Homo sapiens
[BlackBoxEvent:R-HSA-1247915] GSH translocates from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-8943279] GGT dimers hydrolyse GSH - Homo sapiens
[BlackBoxEvent:R-HSA-1247939] CysGly translocates from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-1247910] CNDP2:2Mn2+ dimer hydrolyses CysGly - Homo sapiens
[Reaction:R-HSA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2017-04-20
literatureReference
[LiteratureReference:1295473] Glutathione metabolism and its selective modification
maxDepth
2
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
Glutathione synthesis and recycling
orthologousEvent
[Pathway:R-PFA-174403] Glutathione synthesis and recycling - Plasmodium falciparum
[Pathway:R-SCE-174403] Glutathione synthesis and recycling - Saccharomyces cerevisiae
[Pathway:R-SPO-174403] Glutathione synthesis and recycling - Schizosaccharomyces pombe
[Pathway:R-DDI-174403] Glutathione synthesis and recycling - Dictyostelium discoideum
[Pathway:R-CEL-174403] Glutathione synthesis and recycling - Caenorhabditis elegans
[Pathway:R-DME-174403] Glutathione synthesis and recycling - Drosophila melanogaster
[Pathway:R-GGA-174403] Glutathione synthesis and recycling - Gallus gallus
[Pathway:R-XTR-174403] Glutathione synthesis and recycling - Xenopus tropicalis
[Pathway:R-DRE-174403] Glutathione synthesis and recycling - Danio rerio
[Pathway:R-SSC-174403] Glutathione synthesis and recycling - Sus scrofa
[Pathway:R-BTA-174403] Glutathione synthesis and recycling - Bos taurus
[Pathway:R-CFA-174403] Glutathione synthesis and recycling - Canis familiaris
[Pathway:R-RNO-174403] Glutathione synthesis and recycling - Rattus norvegicus
[Pathway:R-MMU-174403] Glutathione synthesis and recycling - Mus musculus
releaseDate
2008-06-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1299489] D'Eustachio, P, 2011-05-23
revised
[InstanceEdit:1299386] Jassal, B, 2011-05-23
[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-174403
summation
[Summation:211753] The combination of glutamate, cysteine and ATP is required t...
updateTrackers
[UpdateTracker:9790455] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v33:[updateContainedRLE]
[UpdateTracker:9786155] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v50:[updateContainedRLE]
[UpdateTracker:9791953] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v24:[addSummation]
[UpdateTracker:9789848] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v37:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9783903] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v55:[addHasEvent]
[UpdateTracker:9781917] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v60:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9782436] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v59:[addHasEvent, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9790455] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v33:[updateContainedRLE]
[UpdateTracker:9786155] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v50:[updateContainedRLE]
[UpdateTracker:9791953] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v24:[addSummation]
[UpdateTracker:9789848] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v37:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9783903] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v55:[addHasEvent]
[UpdateTracker:9781917] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v60:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9782436] Update Tracker - [Pathway:174403] Glutathione synthesis and recycling - v59:[addHasEvent, updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-156590] Glutathione conjugation
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
