Reactome | Glutathione synthesis and recycling

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Glutathione synthesis and recycling Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911386
displayName	Glutathione synthesis and recycling
eventOf	[Pathway:R-DME-156590] Glutathione conjugation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21534] glutathione metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-1247935] OPLAH hydrolyses OPRO to L-Glu - Drosophila melanogaster [Reaction:R-DME-174367] GCL ligates L-Glu to L-Cys - Drosophila melanogaster [Reaction:R-DME-1247922] GGCT transforms gGluCys to OPRO - Drosophila melanogaster [Reaction:R-DME-174394] GSS:Mg2+ dimer synthesizes GSH - Drosophila melanogaster [Reaction:R-DME-8943279] GGT dimers hydrolyse GSH - Drosophila melanogaster [Reaction:R-DME-1247910] CNDP2:2Mn2+ dimer hydrolyses CysGly - Drosophila melanogaster [Reaction:R-DME-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-174403] Glutathione synthesis and recycling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Glutathione synthesis and recycling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-174403
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-156590] Glutathione conjugation
(inferredTo)	[Pathway:R-HSA-174403] Glutathione synthesis and recycling

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