Reactome | GSS:Mg2+ dimer synthesizes GSH

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GSS:Mg2+ dimer synthesizes GSH Show undefined attributes

catalystActivity	[CatalystActivity:174399] glutathione synthase activity of GSS:Mg2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
crossReference	[DatabaseIdentifier:12668246] RHEA:13558
dbId	174394
diseaseReaction	[FailedReaction:R-HSA-5602901] Defective GSS does not synthesize GSH - Homo sapiens
displayName	GSS:Mg2+ dimer synthesizes GSH
edited	[InstanceEdit:1247945] Jassal, B, 2011-04-08
eventOf	[Pathway:R-HSA-174403] Glutathione synthesis and recycling - Homo sapiens
followingEvent	[Reaction:R-HSA-176059] GST trimers transfer GS from GSH to luminal substrates - Homo sapiens [Reaction:R-HSA-176054] GST dimers conjugate GSH with cytosolic substrates - Homo sapiens [BlackBoxEvent:R-HSA-1247915] GSH translocates from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Homo sapiens [Reaction:R-HSA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-174393] gGluCys [cytosol] [SimpleEntity:R-ALL-29424] Gly [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1247901] Sequencing and expression of a cDNA for human glutathione synthetase [LiteratureReference:5602985] Molecular basis of glutathione synthetase deficiency and a rare gene permutation event
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GSS:Mg2+ dimer synthesizes GSH gamma-glutamylcysteine combines with glycine to form glutathione
orthologousEvent	[Reaction:R-PFA-174394] GSS:Mg2+ dimer synthesizes GSH - Plasmodium falciparum [Reaction:R-MMU-174394] GSS:Mg2+ dimer synthesizes GSH - Mus musculus [Reaction:R-GGA-174394] GSS:Mg2+ dimer synthesizes GSH - Gallus gallus [Reaction:R-SCE-174394] GSS:Mg2+ dimer synthesizes GSH - Saccharomyces cerevisiae [Reaction:R-SPO-174394] GSS:Mg2+ dimer synthesizes GSH - Schizosaccharomyces pombe [Reaction:R-DDI-174394] GSS:Mg2+ dimer synthesizes GSH - Dictyostelium discoideum [Reaction:R-CEL-174394] GSS:Mg2+ dimer synthesizes GSH - Caenorhabditis elegans [Reaction:R-DME-174394] GSS:Mg2+ dimer synthesizes GSH - Drosophila melanogaster [Reaction:R-XTR-174394] GSS:Mg2+ dimer synthesizes GSH - Xenopus tropicalis [Reaction:R-DRE-174394] GSS:Mg2+ dimer synthesizes GSH - Danio rerio [Reaction:R-SSC-174394] GSS:Mg2+ dimer synthesizes GSH - Sus scrofa [Reaction:R-BTA-174394] GSS:Mg2+ dimer synthesizes GSH - Bos taurus [Reaction:R-CFA-174394] GSS:Mg2+ dimer synthesizes GSH - Canis familiaris [Reaction:R-RNO-174394] GSS:Mg2+ dimer synthesizes GSH - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-174367] GCL ligates L-Glu to L-Cys - Homo sapiens [Reaction:R-HSA-1247910] CNDP2:2Mn2+ dimer hydrolyses CysGly - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1260991] Negative regulation by 'GSH [cytosol]'
regulationReference	[RegulationReference:9641341] Negative regulation by 'GSH [cytosol]' Patients with genetic defects in the gamma-glutamyl cycle
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174394
summation	[Summation:178803] In the second step in the formation of glutathione, gamma-gl...
systematicName	GSS:Mg2+ dimer synthesizes GSH
updateTrackers	[UpdateTracker:9786132] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v50:[addLiteratureReference, modifyText] [UpdateTracker:9789611] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v37:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9790721] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v33:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9786132] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v50:[addLiteratureReference, modifyText] [UpdateTracker:9789611] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v37:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9790721] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v33:[addInput]
(precedingEvent)	[Reaction:R-HSA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG [Reaction:R-HSA-176059] GST trimers transfer GS from GSH to luminal substrates [Reaction:R-HSA-176054] GST dimers conjugate GSH with cytosolic substrates [BlackBoxEvent:R-HSA-1247915] GSH translocates from cytosol to extracellular region [Reaction:R-HSA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly
(normalReaction)	[FailedReaction:R-HSA-5602901] Defective GSS does not synthesize GSH
(hasEvent)	[Pathway:R-HSA-174403] Glutathione synthesis and recycling

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