Reactome | OPLAH hydrolyses OPRO to L-Glu

Schema > Reaction > Entries

OPLAH hydrolyses OPRO to L-Glu Show undefined attributes

authored	[InstanceEdit:1247945] Jassal, B, 2011-04-08
catalystActivity	[CatalystActivity:1247941] 5-oxoprolinase (ATP-hydrolyzing) activity of OPLAH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1247945] Jassal, B, 2011-04-08
crossReference	[DatabaseIdentifier:11880964] Rhea:10349
dbId	1247935
displayName	OPLAH hydrolyses OPRO to L-Glu
edited	[InstanceEdit:1247945] Jassal, B, 2011-04-08
eventOf	[Pathway:R-HSA-174403] Glutathione synthesis and recycling - Homo sapiens
followingEvent	[Reaction:R-HSA-174367] GCL ligates L-Glu to L-Cys - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1247942] OPRO [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1247888] Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	OPLAH hydrolyses OPRO to L-Glu Cleavage of 5-oxoproline to form glutamate
orthologousEvent	[Reaction:R-MMU-1247935] OPLAH hydrolyses OPRO to L-Glu - Mus musculus [Reaction:R-SCE-1247935] OPLAH hydrolyses OPRO to L-Glu - Saccharomyces cerevisiae [Reaction:R-SPO-1247935] OPLAH hydrolyses OPRO to L-Glu - Schizosaccharomyces pombe [Reaction:R-DDI-1247935] OPLAH hydrolyses OPRO to L-Glu - Dictyostelium discoideum [Reaction:R-CEL-1247935] OPLAH hydrolyses OPRO to L-Glu - Caenorhabditis elegans [Reaction:R-DME-1247935] OPLAH hydrolyses OPRO to L-Glu - Drosophila melanogaster [Reaction:R-XTR-1247935] OPLAH hydrolyses OPRO to L-Glu - Xenopus tropicalis [Reaction:R-DRE-1247935] OPLAH hydrolyses OPRO to L-Glu - Danio rerio [Reaction:R-SSC-1247935] OPLAH hydrolyses OPRO to L-Glu - Sus scrofa [Reaction:R-BTA-1247935] OPLAH hydrolyses OPRO to L-Glu - Bos taurus [Reaction:R-CFA-1247935] OPLAH hydrolyses OPRO to L-Glu - Canis familiaris [Reaction:R-RNO-1247935] OPLAH hydrolyses OPRO to L-Glu - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-1247922] GGCT transforms gGluCys to OPRO - Homo sapiens [Reaction:R-HSA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1299489] D'Eustachio, P, 2011-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1247935
summation	[Summation:1247897] 5-oxoprolinase catalyzes the cleavage of 5-oxoproline to for...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5603208] Defective OPLAH does not hydrolyse OPRO
(hasEvent)	[Pathway:R-HSA-174403] Glutathione synthesis and recycling
(precedingEvent)	[Reaction:R-HSA-174367] GCL ligates L-Glu to L-Cys