Reactome | Phosphorylation of Cyclin A:Cdk2 at Tyr 15

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Phosphorylation of Cyclin A:Cdk2 at Tyr 15 Show undefined attributes

authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:69254] protein tyrosine kinase activity of WEE1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174164
displayName	Phosphorylation of Cyclin A:Cdk2 at Tyr 15
edited	[InstanceEdit:187878] Matthews, L, 2006-09-28 04:25:14
eventOf	[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry - Homo sapiens
followingEvent	[Reaction:R-HSA-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-141608] CCNA:CDK2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:187925] Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15 [LiteratureReference:213358] Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Phosphorylation of Cyclin A:Cdk2 at Tyr 15
negativePrecedingEvent	[NegativePrecedingEvent:9764011] Futile Cycle: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
orthologousEvent	[Reaction:R-DDI-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Dictyostelium discoideum [Reaction:R-DME-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Drosophila melanogaster [Reaction:R-GGA-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Gallus gallus [Reaction:R-XTR-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Xenopus tropicalis [Reaction:R-DRE-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Danio rerio [Reaction:R-SSC-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Sus scrofa [Reaction:R-BTA-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Bos taurus [Reaction:R-CFA-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Canis familiaris [Reaction:R-RNO-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Rattus norvegicus [Reaction:R-MMU-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-187907] CCNA:p-Y15-CDK2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus - Homo sapiens
regulatedBy	[PositiveRegulation:9605537] Positive regulation by 'CABLES1 [nucleoplasm]'
regulationReference	[RegulationReference:9642766] Positive regulation by 'CABLES1 [nucleoplasm]' Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
releaseDate	2006-11-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174164
summation	[Summation:187984] The CDK activity of the Cyclin A:Cdk2 complex is inhibited b...
updateTrackers	[UpdateTracker:9779347] Update Tracker - [Reaction:174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - v65:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779347] Update Tracker - [Reaction:174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - v65:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry
(precedingEvent)	[Reaction:R-HSA-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2

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