Reactome | Phosphorylation of Cyclin A:Cdk2 at Tyr 15

Schema > Reaction > Entries

Phosphorylation of Cyclin A:Cdk2 at Tyr 15 Show undefined attributes

catalystActivity	[CatalystActivity:9985638] protein tyrosine kinase activity of WEE1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9998675
displayName	Phosphorylation of Cyclin A:Cdk2 at Tyr 15
eventOf	[Pathway:R-MMU-69656] Cyclin A:Cdk2-associated events at S phase entry - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 - Mus musculus
inferredFrom	[Reaction:R-HSA-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-MMU-141608] CCNA:CDK2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of Cyclin A:Cdk2 at Tyr 15
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-MMU-187907] CCNA:p-Y15-CDK2 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus - Mus musculus
regulatedBy	[PositiveRegulation:9985644] Positive regulation by 'CABLES1 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-174164
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-69656] Cyclin A:Cdk2-associated events at S phase entry
(precedingEvent)	[Reaction:R-MMU-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
(inferredTo)	[Reaction:R-HSA-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15

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