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Association of Securin with Cdc20:APC/C complex
Stable Identifier
R-HSA-174121
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Securin is thought to be recognized by the APC/C:Cdc20 complex through its conserved D-box sequence.
Literature References
PubMed ID
Title
Journal
Year
12070128
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
Pines, J
,
Vodermaier, HC
,
Peters, JM
,
Den Elzen, N
,
Hagting, A
,
Waizenegger, IC
J Cell Biol
2002
Participants
Input
CDC20:p-APC/C [cytosol]
(Homo sapiens)
PTTG1 [cytosol]
(Homo sapiens)
Output
CDC20:p-APC/C:PTTG1 [cytosol]
(Homo sapiens)
Participates
as an event of
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Orthologous Events
Association of Securin with Cdc20:APC/C complex (Bos taurus)
Association of Securin with Cdc20:APC/C complex (Canis familiaris)
Association of Securin with Cdc20:APC/C complex (Gallus gallus)
Association of Securin with Cdc20:APC/C complex (Mus musculus)
Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)
Association of Securin with Cdc20:APC/C complex (Sus scrofa)
Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-02-17)
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