Reactome | p-FRS2:CRKL binds C3G

p-FRS2:CRKL binds C3G

Stable Identifier

R-HSA-170978

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        p-FRS2:CRKL binds C3G (Homo sapiens)

General

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Rap guanine nucleotide exchange factor 1 (RAPGEF1, C3G) is a guanine nucleotide exchange factor for Rap1, which is recruited by Crk adaptor proteins (Knudsen et al. 1994; York, 1998).

Literature References

PubMed ID	Title	Journal	Year
7806500	Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk Knudsen, BS, Feller, SM, Hanafusa, H	J Biol Chem	1994
9560161	Rap1 mediates sustained MAP kinase activation induced by nerve growth factor York, RD, Yao, H, Dillon, T, Ellig, CL, Eckert, SP, McCleskey, EW, Stork, PJ	Nature	1998