Reactome | NPC exports GCK1 from nucleus

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NPC exports GCK1 from nucleus Show undefined attributes

category	omitted
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:170815] D'Eustachio, P, 2006-01-17 15:36:38
dbId	170825
displayName	NPC exports GCK1 from nucleus
edited	[InstanceEdit:174827] D'Eustachio, P, 2006-02-20 18:39:56
eventOf	[Pathway:R-HSA-170822] Regulation of Glucokinase by Glucokinase Regulatory Protein - Homo sapiens
followingEvent	[Reaction:R-HSA-170824] glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1021] protein export from nucleus
input	[EntityWithAccessionedSequence:R-HSA-450102] GCK [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:170794] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NPC exports GCK1 from nucleus glucokinase [nucleoplasm] => glucokinase [cytosol]
orthologousEvent	[BlackBoxEvent:R-DRE-170825] NPC exports GCK1 from nucleus - Danio rerio [BlackBoxEvent:R-PFA-170825] NPC exports GCK1 from nucleus - Plasmodium falciparum [BlackBoxEvent:R-SCE-170825] NPC exports GCK1 from nucleus - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-170825] NPC exports GCK1 from nucleus - Schizosaccharomyces pombe [BlackBoxEvent:R-CEL-170825] NPC exports GCK1 from nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-170825] NPC exports GCK1 from nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-170825] NPC exports GCK1 from nucleus - Gallus gallus [BlackBoxEvent:R-BTA-170825] NPC exports GCK1 from nucleus - Bos taurus [BlackBoxEvent:R-XTR-170825] NPC exports GCK1 from nucleus - Xenopus tropicalis [BlackBoxEvent:R-CFA-170825] NPC exports GCK1 from nucleus - Canis familiaris [BlackBoxEvent:R-RNO-170825] NPC exports GCK1 from nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-170825] NPC exports GCK1 from nucleus - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-450094] GCK [cytosol]
precedingEvent	[Reaction:R-HSA-170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939470] Matthews, Lisa, 2025-02-27 [InstanceEdit:9965339] Hill, David P, 2025-08-28
revised	[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-170825
summation	[Summation:170823] Free glucokinase (GCK1) leaves the nucleus via the nuclear p...
updateTrackers	[UpdateTracker:9971816] Update Tracker - [BlackBoxEvent:170825] NPC exports GCK1 from nucleus - v95:[addCatalystActivity] [UpdateTracker:9790913] Update Tracker - [Reaction:170825] glucokinase [nucleoplasm] => glucokinase [cytosol] - v32:[add_removeInput, add_removeOutput, modifyText, removeRegulator] [UpdateTracker:9939831] Update Tracker - [BlackBoxEvent:170825] NPC exports GCK1 from nucleus - v92:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9971816] Update Tracker - [BlackBoxEvent:170825] NPC exports GCK1 from nucleus - v95:[addCatalystActivity] [UpdateTracker:9790913] Update Tracker - [Reaction:170825] glucokinase [nucleoplasm] => glucokinase [cytosol] - v32:[add_removeInput, add_removeOutput, modifyText, removeRegulator] [UpdateTracker:9939831] Update Tracker - [BlackBoxEvent:170825] NPC exports GCK1 from nucleus - v92:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-170822] Regulation of Glucokinase by Glucokinase Regulatory Protein
(precedingEvent)	[Reaction:R-HSA-170824] glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex

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