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Schema
>
Reaction
>
Entries
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
Show undefined attributes
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catalystActivity
[CatalystActivity:9954132] glucose sensor activity of GCK1:GCKR complex [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:170815] D'Eustachio, P, 2006-01-17 15:36:38
dbId
170810
displayName
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
edited
[InstanceEdit:174827] D'Eustachio, P, 2006-02-20 18:39:56
eventOf
[Pathway:R-HSA-170822] Regulation of Glucokinase by Glucokinase Regulatory Protein - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-170825] NPC exports GCK1 from nucleus - Homo sapiens
input
[Complex:R-HSA-170804] GCK1:GCKR complex [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:170794] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
maxDepth
1
modified
[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
Dissociation of the nucleoplasmic GCK1:GCKR complex
orthologousEvent
[Reaction:R-XTR-170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - Xenopus tropicalis
[Reaction:R-CFA-170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - Canis familiaris
[Reaction:R-RNO-170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - Rattus norvegicus
[Reaction:R-MMU-170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-450102] GCK [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-170805] GCKR [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-170796] NPC transports GCK1:GCKR from cytosol to nucleoplasm - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
regulatedBy
[PositiveRegulation:R-HSA-170807] Positive regulation by 'Glc [nucleoplasm]'
releaseDate
2005-06-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9963235] Hill, David P, 2025-08-13
revised
[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-170810
summation
[Summation:170814] In the presence of high glucose concentrations, the complex ...
updateTrackers
[UpdateTracker:9792382] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) - v22:[addLiteratureReference]
[UpdateTracker:9964694] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - v94:[modifyText, removeCatalystActivity]
[UpdateTracker:9791048] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) - v32:[add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9792382] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) - v22:[addLiteratureReference]
[UpdateTracker:9964694] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - v94:[modifyText, removeCatalystActivity]
[UpdateTracker:9791048] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) - v32:[add_removeOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-170822] Regulation of Glucokinase by Glucokinase Regulatory Protein
(precedingEvent)
[BlackBoxEvent:R-HSA-170825] NPC exports GCK1 from nucleus
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