NPC exports GCK1 from nucleus

Stable Identifier
R-HSA-170825
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
glucokinase [nucleoplasm] => glucokinase [cytosol]
ReviewStatus
5/5
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NPC exports GCK1 from nucleus
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Free glucokinase (GCK1) leaves the nucleus via the nuclear pore. While the GCK1 protein contains a nuclear export sequence motif, the molecular details of the GCK1 export process remain to be worked out (Shiota et al. 1999).
Literature References
PubMed ID Title Journal Year
10601273 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

Shiota, C, Coffey, J, Grimsby, J, Grippo, JF, Magnuson, MA

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
nuclear transport (0051169)
Catalyst Activity

structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
structural constituent of nuclear pore (GO:0017056)
Orthologous Events
NPC exports GCK1 from nucleus (Bos taurus)
NPC exports GCK1 from nucleus (Canis familiaris)
NPC exports GCK1 from nucleus (Drosophila melanogaster)
NPC exports GCK1 from nucleus (Gallus gallus)
NPC exports GCK1 from nucleus (Mus musculus)
NPC exports GCK1 from nucleus (Rattus norvegicus)
NPC exports GCK1 from nucleus (Saccharomyces cerevisiae)
NPC exports GCK1 from nucleus (Schizosaccharomyces pombe)
NPC exports GCK1 from nucleus (Xenopus tropicalis)
Reviewed
Matthews, L  (2025-02-27)
Created
D'Eustachio, P  (2006-01-17)
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