Reactome | glucokinase [nucleoplasm] => glucokinase [cytosol]

glucokinase [nucleoplasm] => glucokinase [cytosol]

Stable Identifier

R-HSA-170825

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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glucokinase [nucleoplasm] => glucokinase [cytosol]

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Free glucokinase (GCK1) leaves the nucleus via the nuclear pore. While the GCK1 protein contains a nuclear export sequence motif, the molecular details of the GCK1 export process remain to be worked out (Shiota et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10601273	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase Magnuson, MA, Grimsby, J, Shiota, C, Coffey, J, Grippo, JF	J Biol Chem	1999