nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)

Stable Identifier
R-HSA-170810
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Dissociation of the nucleoplasmic GCK1:GCKR complex
ReviewStatus
5/5
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nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
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In the presence of high glucose concentrations, the complex of nucleoplasmic glucokinase (GCK1) and glucokinase regulatory protein (GCKR) dissociates (Shiota et al. 1999).
Literature References
PubMed ID Title Journal Year
10601273 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

Shiota, C, Coffey, J, Grimsby, J, Grippo, JF, Magnuson, MA

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucose sensor activity of GCK1:GCKR complex [nucleoplasm]

Physical Entity
GCK1:GCKR complex [nucleoplasm] (Homo sapiens)
Activity
glucose sensor activity (GO:0141089)
This event is regulated
Positively by
Regulator
Glc [nucleoplasm]
Orthologous Events
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) (Canis familiaris)
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) (Mus musculus)
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) (Rattus norvegicus)
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) (Xenopus tropicalis)
Reviewed
Hill, DP  (2025-08-13)
Created
D'Eustachio, P  (2006-01-17)
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