Reactome | TLR6:TLR2 is recruited to ligand:CD14:CD36

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TLR6:TLR2 is recruited to ligand:CD14:CD36 Show undefined attributes

authored	[InstanceEdit:179395] D'Eustachio, P, Gay, NJ, Gale M, Jr, Zwaginga, JJ, 2006-04-19 04:09:58
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:168943] de Bono, B, 2005-11-22 18:44:27
dbId	168950
displayName	TLR6:TLR2 is recruited to ligand:CD14:CD36
edited	[InstanceEdit:2603258] Shamovsky, V, 2012-11-19
eventOf	[Pathway:R-HSA-168188] Toll Like Receptor TLR6:TLR2 Cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-2201316] Activated TLR2/4 interacts with MAL (TIRAP) - Homo sapiens
input	[Complex:R-HSA-2559461] TLR6/2 ligand:CD14:CD36 [plasma membrane] [Complex:R-HSA-168949] TLR6:TLR2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:180828] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [LiteratureReference:181143] Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin [LiteratureReference:181127] Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components [LiteratureReference:181125] Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis [LiteratureReference:181032] Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2 [LiteratureReference:181943] Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6 [LiteratureReference:9630198] The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR6:TLR2 is recruited to ligand:CD14:CD36
output	[Complex:R-HSA-181410] TLR6:TLR2:ligand:CD14:CD36 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2559464] TLR6/2 ligand associates with CD14 and CD36 within lipid rafts - Homo sapiens
relatedSpecies	[Species:181384] Chlamydia trachomatis
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168950
summation	[Summation:181955] TLR2 - in combination with TLR6 - plays a major role in reco...
updateTrackers	[UpdateTracker:9788272] Update Tracker - [Reaction:168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 - v43:[addLiteratureReference, add_removeInput, modifyText] [UpdateTracker:9778018] Update Tracker - [Reaction:168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 - v68:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9788272] Update Tracker - [Reaction:168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 - v43:[addLiteratureReference, add_removeInput, modifyText] [UpdateTracker:9778018] Update Tracker - [Reaction:168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 - v68:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-168188] Toll Like Receptor TLR6:TLR2 Cascade
(precedingEvent)	[Reaction:R-HSA-2201316] Activated TLR2/4 interacts with MAL (TIRAP)

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