Reactome | TLR6/2 ligand associates with CD14 and CD36 within lipid rafts

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TLR6/2 ligand associates with CD14 and CD36 within lipid rafts Show undefined attributes

authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2559467] Shamovsky, V, 2012-11-02
dbId	2559464
displayName	TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
edited	[InstanceEdit:2586621] Shamovsky, V, 2012-11-16
eventOf	[Pathway:R-HSA-168188] Toll Like Receptor TLR6:TLR2 Cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-51645] 4xPalmC-CD36 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-166033] GPIN-CD14(20-345) [plasma membrane] [DefinedSet:R-CTR-9628992] TLR6:TLR2 recognized ligand [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2428886] Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting [LiteratureReference:9630198] The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
output	[Complex:R-HSA-2559461] TLR6/2 ligand:CD14:CD36 [plasma membrane]
relatedSpecies	[Species:181384] Chlamydia trachomatis
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2559464
summation	[Summation:2559465] Scavenger receptor CD36 has been reported to function as an ...
updateTrackers	[UpdateTracker:9778151] Update Tracker - [Reaction:2559464] TLR6/2 ligand associates with CD14 and CD36 within lipid rafts - v68:[addLiteratureReference] [UpdateTracker:9778838] Update Tracker - [Reaction:2559464] TLR6/2 ligand associates with CD14 and CD36 within lipid rafts - v67:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778151] Update Tracker - [Reaction:2559464] TLR6/2 ligand associates with CD14 and CD36 within lipid rafts - v68:[addLiteratureReference] [UpdateTracker:9778838] Update Tracker - [Reaction:2559464] TLR6/2 ligand associates with CD14 and CD36 within lipid rafts - v67:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-168188] Toll Like Receptor TLR6:TLR2 Cascade
(precedingEvent)	[Reaction:R-HSA-168950] TLR6:TLR2 is recruited to ligand:CD14:CD36