Reactome | Activated TLR2/4 interacts with MAL (TIRAP)

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Activated TLR2/4 interacts with MAL (TIRAP) Show undefined attributes

authored	[InstanceEdit:2201346] Shamovsky, V, 2012-04-19
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2201327] Shamovsky, V, 2012-04-19
dbId	2201316
displayName	Activated TLR2/4 interacts with MAL (TIRAP)
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-2559414] Activated TLR2/4:TIRAP interacts with BTK - Homo sapiens
input	[DefinedSet:R-HSA-181230] Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] 2 × [Complex:R-HSA-2559415] TIRAP:PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:936981] A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors [LiteratureReference:181352] Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 [LiteratureReference:2428866] MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TLR2/4 interacts with MAL (TIRAP)
output	[Complex:R-HSA-2559411] TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane]
precedingEvent	[Reaction:R-HSA-168951] TLR1:TLR2 is recruited to ligand:CD14 - Homo sapiens [Reaction:R-HSA-168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 - Homo sapiens [Reaction:R-HSA-166041] Transfer of LPS onto TLR4 - Homo sapiens [Reaction:R-HSA-8870678] Cleaved fibrinogen products bind TLR4:LY96 - Homo sapiens [Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96 - Homo sapiens [Reaction:R-HSA-6805943] S100A1 binds TLR4:LY96 - Homo sapiens [Reaction:R-HSA-5432849] S100A8:S100A9 binds TLR4:LY96 - Homo sapiens
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2201316
summation	[Summation:937057] TIRAP/Mal-deficient mice showed normal responses to the TLR3...
updateTrackers	[UpdateTracker:9788179] Update Tracker - [Reaction:2201316] Activated TLR2/4 interacts with MAL (TIRAP) - v43:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788179] Update Tracker - [Reaction:2201316] Activated TLR2/4 interacts with MAL (TIRAP) - v43:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-HSA-2559414] Activated TLR2/4:TIRAP interacts with BTK