TLR6:TLR2 is recruited to ligand:CD14:CD36

Stable Identifier
R-HSA-168950
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Chlamydia trachomatis
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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TLR6:TLR2 is recruited to ligand:CD14:CD36
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TLR2 - in combination with TLR6 - plays a major role in recognizing lipoteichoic acid (LTA) and peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides.
Literature References
PubMed ID Title Journal Year
10426996 Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

Aliprantis, AO, Yang, RB, Mark, MR, Suggett, S, Devaux, B, Radolf, JD, Klimpel, GR, Godowski, P, Zychlinsky, A

Science 1999
10364168 Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

Schwandner, R, Dziarski, R, Wesche, H, Rothe, M, Kirschning, CJ

J Biol Chem 1999
10490993 Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis

Means, TK, Wang, S, Lien, E, Yoshimura, A, Golenbock, DT, Fenton, MJ

J Immunol 1999
14977973 Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6

Okusawa, T, Fujita, M, Nakamura, J, Into, T, Yasuda, M, Yoshimura, A, Hara, Y, Hasebe, A, Golenbock, DT, Morita, M, Kuroki, Y, Ogawa, T, Shibata, K

Infect Immun 2004
10549626 Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Takeuchi, O, Hoshino, K, Kawai, T, Sanjo, H, Takada, H, Ogawa, T, Takeda, K, Akira, S

Immunity 1999
11123271 Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

Hajjar, AM, O'Mahony, DS, Ozinsky, A, Underhill, DM, Aderem, A, Klebanoff, SJ, Wilson, CB

J Immunol 2001
18178856 The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14

Bas, S, Neff, L, Vuillet, M, Spenato, U, Seya, T, Matsumoto, M, Gabay, C

J. Immunol. 2008
Participants
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Output
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Authored
D'Eustachio, P  (2006-04-19)
Gay, NJ  (2006-04-19)
Gale M, Jr  (2006-04-19)
Zwaginga, JJ  (2006-04-19)
Reviewed
D'Eustachio, P  (2006-07-04)
Gillespie, ME  (2010-11-30)
Created
de Bono, B  (2005-11-22)
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