TLR6:TLR2 is recruited to ligand:CD14:CD36

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Chlamydia trachomatis
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TLR2 - in combination with TLR6 - plays a major role in recognizing lipoteichoic acid (LTA) and peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides.

Literature References
PubMed ID Title Journal Year
10426996 Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

Zychlinsky, A, Klimpel, GR, Devaux, B, Yang, RB, Radolf, JD, Mark, MR, Suggett, S, Godowski, P, Aliprantis, AO

Science 1999
10364168 Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

Schwandner, R, Wesche, H, Kirschning, CJ, Rothe, M, Dziarski, R

J Biol Chem 1999
10490993 Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis

Wang, S, Means, TK, Fenton, MJ, Golenbock, DT, Lien, E, Yoshimura, A

J Immunol 1999
14977973 Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6

Hasebe, A, Shibata, K, Into, T, Hara, Y, Nakamura, J, Ogawa, T, Morita, M, Fujita, M, Golenbock, DT, Yasuda, M, Kuroki, Y, Okusawa, T, Yoshimura, A

Infect Immun 2004
10549626 Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Akira, S, Ogawa, T, Takada, H, Kawai, T

Immunity 1999
11123271 Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

Wilson, CB, Underhill, DM, Hajjar, AM, Ozinsky, A, O'Mahony, DS, Aderem, A, Klebanoff, SJ

J Immunol 2001
18178856 The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14

Matsumoto, M, Bas, S, Gabay, C, Seya, T, Vuillet, M, Spenato, U, Neff, L

J. Immunol. 2008
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