Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)

Stable Identifier
R-HSA-168092
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane, endosome lumen
ReviewStatus
5/5
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Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
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Viral dsRNA triggers an antiviral pathway mediated by toll like receptor 3. TLR3 dimerization occurs upon ligand binding to positively charged residues on the ectodomain termini of TLR3 which are responsible for the interaction with sugar-phosphate groups of dsRNA.

Literature References
PubMed ID Title Journal Year
18420935 Structural basis of toll-like receptor 3 signaling with double-stranded RNA

Davies, DR, Leonard, JN, Shiloach, J, Botos, I, Liu, L, Wang, Y, Segal, DM

Science 2008
11607032 Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

Holt, AC, Alexopoulou, L, Medzhitov, R, Flavell, RA

Nature 2001
Participants
Input
Output
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as an event of
Authored
Luo, F  (2005-11-10)
Reviewed
Gay, NJ  (2006-04-24)
Created
Gillespie, ME  (2005-11-10)
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