Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)

Stable Identifier
R-HSA-168092
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane, endosome lumen
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Viral dsRNA triggers an antiviral pathway mediated by toll like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.

Literature References
PubMed ID Title Journal Year
11607032 Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

Alexopoulou, L, Holt, AC, Medzhitov, R, Flavell, RA

Nature 2001
18420935 Structural basis of toll-like receptor 3 signaling with double-stranded RNA

Liu, L, Botos, I, Wang, Y, Leonard, JN, Shiloach, J, Segal, DM, Davies, DR

Science 2008
Participants
Input
Output
Participant Of
hasEvent
Authored
Luo, F  (2005-11-10)
Reviewed
Gay, NJ  (2006-04-24)
Created
Gillespie, ME  (2005-11-10)