GUSB tetramer hydrolyses CS/HS precursor

Stable Identifier
R-HSA-1678854
Type
Reaction
Species
Homo sapiens
Compartment
lysosomal lumen
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GUSB tetramer hydrolyses CS/HS precursor
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The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from heparan or the linker chain (Oshima et al. 1987). L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References
PubMed ID Title Journal Year
3468507 Cloning, sequencing, and expression of cDNA for human beta-glucuronidase

Kyle, JW, Gravel, RA, Powell, PP, Tropak, M, Sly, WS, Miller, RD, Grubb, JH, Oshima, A, Guise, KS, Hoffmann, JW

Proc Natl Acad Sci U S A 1987
11568288 A novel inhibitor of beta-glucuronidase: L-aspartic acid

Siegel, FL, Kreamer, BL, Gourley, GR

Pediatr Res 2001
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as an event of
Catalyst Activity

beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]

Physical Entity
GUSB tetramer [lysosomal lumen] (Homo sapiens)
Activity
beta-glucuronidase activity (GO:0004566)
This event is regulated
Negatively by
Regulator
L-Asp [lysosomal lumen]
Orthologous Events
GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)
GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)
GUSB tetramer hydrolyses CS/HS precursor (Danio rerio)
GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)
GUSB tetramer hydrolyses CS/HS precursor (Gallus gallus)
GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)
GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)
GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)
GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-19)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-19)
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