Reactome | GUSB tetramer hydrolyses CS/HS precursor

GUSB tetramer hydrolyses CS/HS precursor

Stable Identifier

R-HSA-1678854

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen

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GUSB tetramer hydrolyses CS/HS precursor

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The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from heparan or the linker chain (Oshima et al. 1987). L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11568288	A novel inhibitor of beta-glucuronidase: L-aspartic acid Kreamer, BL, Siegel, FL, Gourley, GR	Pediatr Res	2001
3468507	Cloning, sequencing, and expression of cDNA for human beta-glucuronidase Oshima, A, Kyle, JW, Miller, RD, Hoffmann, JW, Powell, PP, Grubb, JH, Sly, WS, Tropak, M, Guise, KS, Gravel, RA	Proc Natl Acad Sci U S A	1987