GUSB tetramer hydrolyses CS/HS precursor

Stable Identifier
R-HSA-1678854
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal lumen
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GUSB tetramer hydrolyses CS/HS precursor
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The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from heparan or the linker chain (Oshima et al. 1987). L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References
PubMed ID Title Journal Year
11568288 A novel inhibitor of beta-glucuronidase: L-aspartic acid

Kreamer, BL, Siegel, FL, Gourley, GR

Pediatr Res 2001
3468507 Cloning, sequencing, and expression of cDNA for human beta-glucuronidase

Oshima, A, Kyle, JW, Miller, RD, Hoffmann, JW, Powell, PP, Grubb, JH, Sly, WS, Tropak, M, Guise, KS, Gravel, RA

Proc Natl Acad Sci U S A 1987
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]
Physical Entity
GUSB tetramer [lysosomal lumen]
Activity
beta-glucuronidase activity (0004566)
This event is regulated
Negatively by
Orthologous Events
GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)
GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)
GUSB tetramer hydrolyses CS/HS precursor (Danio rerio)
GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)
GUSB tetramer hydrolyses CS/HS precursor (Gallus gallus)
GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)
GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)
GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)
GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-19)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-19)
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