Reactome | GUSB tetramer hydrolyses CS/HS precursor

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GUSB tetramer hydrolyses CS/HS precursor Show undefined attributes

catalystActivity	[CatalystActivity:10864475] beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10864477
displayName	GUSB tetramer hydrolyses CS/HS precursor
eventOf	[Pathway:R-DME-2024101] CS/DS degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-2090079] GLB1 hydrolyses linker chain(2) - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1678854] GUSB tetramer hydrolyses CS/HS precursor - Homo sapiens
input	[SimpleEntity:R-ALL-2065212] CS/HS precursor [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GUSB tetramer hydrolyses CS/HS precursor
output	[SimpleEntity:R-ALL-1678868] GlcA [lysosomal lumen] [SimpleEntity:R-ALL-2090075] linker chain(2) [lysosomal lumen]
precedingEvent	[Reaction:R-DME-2090038] NAGLU hydrolyses heparan chain(2) - Drosophila melanogaster
regulatedBy	[NegativeRegulation:R-HSA-2090086] Negative regulation by 'L-Asp [lysosomal lumen]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1678854
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2024101] CS/DS degradation
(precedingEvent)	[Reaction:R-DME-2090079] GLB1 hydrolyses linker chain(2)
(inferredTo)	[Reaction:R-HSA-1678854] GUSB tetramer hydrolyses CS/HS precursor

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