Reactome | GLB1 hydrolyses linker chain(2)

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GLB1 hydrolyses linker chain(2) Show undefined attributes

authored	[InstanceEdit:2090024] Jassal, B, 2012-02-06
catalystActivity	[CatalystActivity:1605789] beta-galactosidase activity of BGAL [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2090024] Jassal, B, 2012-02-06
dbId	2090079
diseaseReaction	[FailedReaction:R-HSA-9036061] Defective GLB1 does not hydrolyse linker chain(2) - Homo sapiens
displayName	GLB1 hydrolyses linker chain(2)
edited	[InstanceEdit:2090024] Jassal, B, 2012-02-06
eventOf	[Pathway:R-HSA-2024101] CS/DS degradation - Homo sapiens
input	2 × [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-2090075] linker chain(2) [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605727] Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase [LiteratureReference:1605704] Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases [LiteratureReference:1605739] Human beta-galactosidase gene mutations in morquio B disease
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	GLB1 hydrolyses linker chain(2)
orthologousEvent	[Reaction:R-BTA-2090079] GLB1 hydrolyses linker chain(2) - Bos taurus [Reaction:R-DDI-2090079] GLB1 hydrolyses linker chain(2) - Dictyostelium discoideum [Reaction:R-CEL-2090079] GLB1 hydrolyses linker chain(2) - Caenorhabditis elegans [Reaction:R-DME-2090079] GLB1 hydrolyses linker chain(2) - Drosophila melanogaster [Reaction:R-GGA-2090079] GLB1 hydrolyses linker chain(2) - Gallus gallus [Reaction:R-XTR-2090079] GLB1 hydrolyses linker chain(2) - Xenopus tropicalis [Reaction:R-SSC-2090079] GLB1 hydrolyses linker chain(2) - Sus scrofa [Reaction:R-RNO-2090079] GLB1 hydrolyses linker chain(2) - Rattus norvegicus [Reaction:R-MMU-2090079] GLB1 hydrolyses linker chain(2) - Mus musculus
output	[SimpleEntity:R-ALL-2090063] D-xylose [lysosomal lumen] 2 × [SimpleEntity:R-ALL-1605637] Gal [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1678854] GUSB tetramer hydrolyses CS/HS precursor - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2090079
summation	[Summation:1630302] Beta-galactosidase (GLB1) can cleave terminal galactose resi...
updateTrackers	[UpdateTracker:9788449] Update Tracker - [Reaction:2090079] GLB1 hydrolyses linker chain(2) - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788449] Update Tracker - [Reaction:2090079] GLB1 hydrolyses linker chain(2) - v42:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-9036061] Defective GLB1 does not hydrolyse linker chain(2)
(hasEvent)	[Pathway:R-HSA-2024101] CS/DS degradation