Reactome | PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane

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PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10036081] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10036083
displayName	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
eventOf	[Pathway:R-MMU-1660499] Synthesis of PIPs at the plasma membrane - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Mus musculus [Reaction:R-MMU-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Mus musculus [Reaction:R-MMU-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
precedingEvent	[Reaction:R-MMU-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Mus musculus [Reaction:R-MMU-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Mus musculus [Reaction:R-MMU-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1676149
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1660499] Synthesis of PIPs at the plasma membrane
(inferredTo)	[Reaction:R-HSA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
(precedingEvent)	[Reaction:R-MMU-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Reaction:R-MMU-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-MMU-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane