Reactome | PI4P is dephosphorylated to PI by SACM1L at the ER membrane

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PI4P is dephosphorylated to PI by SACM1L at the ER membrane Show undefined attributes

catalystActivity	[CatalystActivity:10939277] phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
dbId	10939279
displayName	PI4P is dephosphorylated to PI by SACM1L at the ER membrane
eventOf	[Pathway:R-PFA-1483248] Synthesis of PIPs at the ER membrane - Plasmodium falciparum
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-1483219] PC is exchanged with PI by PITPNB - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806234] PI4P [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
name	PI4P is dephosphorylated to PI by SACM1L at the ER membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-PFA-8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane - Plasmodium falciparum [Reaction:R-PFA-8868402] OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane - Plasmodium falciparum
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-1676124
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-1483248] Synthesis of PIPs at the ER membrane
(precedingEvent)	[Reaction:R-PFA-1483219] PC is exchanged with PI by PITPNB
(inferredTo)	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane