Reactome | PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

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PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806239] 1-phosphatidylinositol 4-kinase activity of PI4KA/2B [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:11880562] Rhea:19877
dbId	1675813
displayName	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676142] Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230 [LiteratureReference:1675796] Subcellular locations of phosphatidylinositol 4-kinase isoforms [LiteratureReference:1675991] Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
orthologousEvent	[Reaction:R-XTR-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Xenopus tropicalis [Reaction:R-CFA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Canis familiaris [Reaction:R-SCE-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Schizosaccharomyces pombe [Reaction:R-CEL-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Caenorhabditis elegans [Reaction:R-DME-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Drosophila melanogaster [Reaction:R-DDI-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Dictyostelium discoideum [Reaction:R-GGA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Gallus gallus [Reaction:R-DRE-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Danio rerio [Reaction:R-SSC-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Sus scrofa [Reaction:R-BTA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Bos taurus [Reaction:R-RNO-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Rattus norvegicus [Reaction:R-MMU-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806234] PI4P [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Homo sapiens [Reaction:R-HSA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens [Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens [Reaction:R-HSA-1482976] CDP-DAG is converted to PI by CDIPT - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1675813
summation	[Summation:1676062] At the endoplasmic reticulum (ER) membrane, phosphatidylinos...

Referrals

(hasEvent)	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane
(precedingEvent)	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane

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