Reactome | PI4P is dephosphorylated to PI by SACM1L at the ER membrane

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PI4P is dephosphorylated to PI by SACM1L at the ER membrane Show undefined attributes

catalystActivity	[CatalystActivity:10864305] phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10864307
displayName	PI4P is dephosphorylated to PI by SACM1L at the ER membrane
eventOf	[Pathway:R-DME-1483248] Synthesis of PIPs at the ER membrane - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Drosophila melanogaster [Reaction:R-DME-1483219] PC is exchanged with PI by PITPNB - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806234] PI4P [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI4P is dephosphorylated to PI by SACM1L at the ER membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-DME-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Drosophila melanogaster [Reaction:R-DME-8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane - Drosophila melanogaster [Reaction:R-DME-8868402] OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane - Drosophila melanogaster [Reaction:R-DME-8867876] OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1676124
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1483248] Synthesis of PIPs at the ER membrane
(precedingEvent)	[Reaction:R-DME-1483219] PC is exchanged with PI by PITPNB [Reaction:R-DME-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
(inferredTo)	[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane