PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane

Stable Identifier
R-HSA-1675939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
early endosome membrane, cytosol
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PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
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At the early endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 complex (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).

Literature References
PubMed ID Title Journal Year
8999962 Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

Panaretou, C, Domin, J, Cockcroft, S, Waterfield, MD

J Biol Chem 1997
7628435 A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

Volinia, S, Dhand, R, Vanhaesebroeck, B, MacDougall, LK, Stein, R, Zvelebil, MJ, Domin, J, Panaretou, C, Waterfield, MD

EMBO J 1995
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J

Mol Cell Biol 2000
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Domin, J, Gaidarov, I, Smith, ME, Keen, JH, Waterfield, MD

J Biol Chem 2000
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP

Traffic 2007
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-3-kinase activity of PIK3C2A/3 [cytosol]
Physical Entity
PIK3C2A/3 [cytosol]
Activity
1-phosphatidylinositol-3-kinase activity (0016303)
Orthologous Events
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Gallus gallus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Rattus norvegicus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)