PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the early endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 complex (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Literature References
PubMed ID Title Journal Year
7628435 A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

Waterfield, MD, Dhand, R, Stein, R, MacDougall, LK, Vanhaesebroeck, B, Volinia, S, Zvelebil, MJ, Domin, J, Panaretou, C

EMBO J 1995
8999962 Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

Waterfield, MD, Domin, J, Panaretou, C, Cockcroft, S

J Biol Chem 1997
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J

Mol Cell Biol 2000
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH

J Biol Chem 2000
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM

Traffic 2007
Catalyst Activity

1-phosphatidylinositol-3-kinase activity of PIK3C2A/3 [cytosol]

Orthologous Events
Cross References
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