At the early endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 complex (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Waterfield, MD, Dhand, R, Stein, R, MacDougall, LK, Vanhaesebroeck, B, Volinia, S, Zvelebil, MJ, Domin, J, Panaretou, C
Waterfield, MD, Domin, J, Panaretou, C, Cockcroft, S
Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J
Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH
Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM
1-phosphatidylinositol-3-kinase activity of PIK3C2A/3 [cytosol]
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