Reactome | MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa

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MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166722] de Bono, B, 2005-09-15 14:24:26
dbId	166721
displayName	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
eventOf	[Pathway:R-HSA-166662] Lectin pathway of complement activation - Homo sapiens
followingEvent	[Reaction:R-HSA-166726] Activation of MASPs - Homo sapiens
input	[OtherEntity:R-ALL-166718] Bacterial mannose surface pattern [plasma membrane] 4 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [Complex:R-HSA-166710] MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182411] Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition [LiteratureReference:166677] The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases [LiteratureReference:166709] The lectin-complement pathway--its role in innate immunity and evolution [LiteratureReference:174542] The mannan-binding lectin pathway of complement activation: biology and disease association
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
orthologousEvent	[Reaction:R-SSC-166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - Sus scrofa [Reaction:R-BTA-166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - Bos taurus [Reaction:R-RNO-166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - Rattus norvegicus [Reaction:R-MMU-166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - Mus musculus
output	[Complex:R-HSA-166719] MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166721
summation	[Summation:182428] The MBL polypeptide chain consists of a short N-terminal cys...
updateTrackers	[UpdateTracker:9787454] Update Tracker - [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - v45:[addLiteratureReference, modifyText] [UpdateTracker:9783594] Update Tracker - [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - v56:[modifyText]

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(updatedInstance)	[UpdateTracker:9787454] Update Tracker - [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - v45:[addLiteratureReference, modifyText] [UpdateTracker:9783594] Update Tracker - [Reaction:166721] MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa - v56:[modifyText]
(hasEvent)	[Pathway:R-HSA-166662] Lectin pathway of complement activation
(precedingEvent)	[Reaction:R-HSA-166726] Activation of MASPs