Reactome | Conversion of C2 into C2a and C2b

Schema > Reaction > Entries

Conversion of C2 into C2a and C2b Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
catalystActivity	[CatalystActivity:166764] serine-type endopeptidase activity of C4 activators [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166791] de Bono, B, 2005-09-16 12:35:57
dbId	166792
displayName	Conversion of C2 into C2a and C2b
eventOf	[Pathway:R-HSA-166663] Initial triggering of complement - Homo sapiens
followingEvent	[Reaction:R-HSA-166795] Formation of Classical C3 convertase (C4b:C2a complex) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-166778] C2 [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:166769] The biological functions of MBL-associated serine proteases (MASPs) [LiteratureReference:182412] Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2 [LiteratureReference:182438] Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b [LiteratureReference:182436] Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Conversion of C2 into C2a and C2b
output	[EntityWithAccessionedSequence:R-HSA-166780] C2a [extracellular region] [EntityWithAccessionedSequence:R-HSA-166781] C2b [extracellular region]
precedingEvent	[Reaction:R-HSA-166726] Activation of MASPs - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166792
summation	[Summation:174561] C2 is cleaved into the large C2a and the small C2b fragment....
updateTrackers	[UpdateTracker:9788873] Update Tracker - [Reaction:166792] Conversion of C2 into C2a and C2b - v40:[modifyText] [UpdateTracker:9790033] Update Tracker - [Reaction:166792] Conversion of C2 into C2a and C2b - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788873] Update Tracker - [Reaction:166792] Conversion of C2 into C2a and C2b - v40:[modifyText] [UpdateTracker:9790033] Update Tracker - [Reaction:166792] Conversion of C2 into C2a and C2b - v35:[modifyText]
(hasEvent)	[Pathway:R-HSA-166663] Initial triggering of complement
(precedingEvent)	[Reaction:R-HSA-166795] Formation of Classical C3 convertase (C4b:C2a complex)