Reactome | TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)

Schema > Reaction > Entries

TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459001
displayName	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
eventOf	[Pathway:R-SSC-166166] MyD88-independent TLR4 cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Sus scrofa [Reaction:R-SSC-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Sus scrofa [Reaction:R-SSC-936985] Activated TLR4:TICAM1 recruits TRAF6 - Sus scrofa
inferredFrom	[Reaction:R-HSA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-SSC-166170] TICAM1 [cytosol] [Complex:R-SSC-166163] TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
output	[Complex:R-SSC-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-166175
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-166166] MyD88-independent TLR4 cascade
(precedingEvent)	[Reaction:R-SSC-2201338] TRAF3 binds TICAM1:activated TLR4 complex [Reaction:R-SSC-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Reaction:R-SSC-936985] Activated TLR4:TICAM1 recruits TRAF6
(inferredTo)	[Reaction:R-HSA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)

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