Reactome | MyD88-independent TLR4 cascade

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MyD88-independent TLR4 cascade Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825883
displayName	MyD88-independent TLR4 cascade
eventOf	[Pathway:R-GGA-166016] Toll Like Receptor 4 (TLR4) Cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263660] MyD88-independent toll-like receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Gallus gallus [Reaction:R-GGA-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 - Gallus gallus [Pathway:R-GGA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Gallus gallus
inferredFrom	[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	7
name	MyD88-independent TLR4 cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-166166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-166016] Toll Like Receptor 4 (TLR4) Cascade
(hasEncapsulatedEvent)	[Pathway:R-GGA-140534] Caspase activation via Death Receptors in the presence of ligand [Pathway:R-GGA-5357769] Caspase activation via extrinsic apoptotic signalling pathway
(inferredTo)	[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade

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