Reactome | IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]

Schema > Complex > Entries

IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:166099] de Bono, B, 2005-08-17 10:44:00
dbId	166100
displayName	IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]
hasComponent	4 × [DefinedSet:R-HSA-937026] IRAK1/ IRAK2 [plasma membrane] [Complex:R-HSA-937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-GGA-977244] IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane] - Gallus gallus [Complex:R-GGA-434002] IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane] - Gallus gallus
literatureReference	[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling [LiteratureReference:571295] Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases [LiteratureReference:2428888] Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction [LiteratureReference:2428820] IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)
maxDepth	10
modified	[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
name	IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:Mal:activated TLR
producedByEvent	[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - Homo sapiens
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-166100
updateTrackers	[UpdateTracker:9889381] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v49:[updateContainedComponent] [UpdateTracker:9899779] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9896454] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v60:[removeSpecies, updateContainedComponent] [UpdateTracker:9890571] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v52:[updateContainedComponent] [UpdateTracker:9874058] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9872001] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9901950] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v76:[updateContainedComponent] [UpdateTracker:9867519] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v25:[updateContainedComponent] [UpdateTracker:9868745] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v32:[updateContainedComponent] [UpdateTracker:9863788] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v20:[updateContainedComponent] [UpdateTracker:9870223] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v38:[updateContainedComponent] [UpdateTracker:9895780] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9892932] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v54:[updateContainedComponent] [UpdateTracker:9899608] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v66:[addName, updateContainedComponent] [UpdateTracker:9868462] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v31:[updateContainedComponent] [UpdateTracker:9870983] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9873203] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]

Referrals

(updatedInstance)

(output)

[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex

© 2026 Reactome

Cite Us!