Reactome | Terminal (3' end) cleavage of viral DNA

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Terminal (3' end) cleavage of viral DNA Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:164501] D'Eustachio, P, 2005-05-24 15:07:45
dbId	164522
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Terminal (3' end) cleavage of viral DNA
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-162592] Integration of provirus - Homo sapiens
figure	[Figure:175999] /figures/endpro1x.jpg
followingEvent	[Reaction:R-HSA-162590] Import of PIC to the Host Nucleus - Homo sapiens
input	[Complex:R-HSA-177532] viral DNA bound with Integrase in PIC [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:175685] Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein [Book:175927] 9780879695712 Integration Retroviruses Coffin, JM [LiteratureReference:175622] HIV cDNA integration: molecular biology and inhibitor development [Book:175907] 9781461559252 Retroviral cDNA integration: mechanism, applications and inhibition Genetic Engineering: Principles and Methods Setlow, Jane K
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Terminal (3' end) cleavage of viral DNA
output	[Complex:R-HSA-177526] IN bound to sticky 3' ends of viral DNA in PIC [cytosol]
precedingEvent	[Reaction:R-HSA-164514] Integrase binds viral DNA ends - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188934] Bushman, FD, 2006-10-30 22:19:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164522
summation	[Summation:180400] Prior to integration, two nucleotides are removed from each ...

Referrals

(hasEvent)	[Pathway:R-HSA-162592] Integration of provirus
(precedingEvent)	[Reaction:R-HSA-162590] Import of PIC to the Host Nucleus