Reactome | Integrase binds viral DNA ends

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Integrase binds viral DNA ends Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:164501] D'Eustachio, P, 2005-05-24 15:07:45
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164514
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Integrase binds viral DNA ends
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-162592] Integration of provirus - Homo sapiens
figure	[Figure:188488] /figures/integ_binding.jpg
followingEvent	[Reaction:R-HSA-164522] Terminal (3' end) cleavage of viral DNA - Homo sapiens
input	[Complex:R-HSA-175143] PIC (PreIntegration Complex) [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:175676] Retroviral DNA integration directed by HIV integration protein in vitro [Book:175927] 9780879695712 Integration Retroviruses Coffin, JM [LiteratureReference:175622] HIV cDNA integration: molecular biology and inhibitor development [Book:175907] 9781461559252 Retroviral cDNA integration: mechanism, applications and inhibition Genetic Engineering: Principles and Methods Setlow, Jane K
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Integrase binds viral DNA ends
output	[Complex:R-HSA-177532] viral DNA bound with Integrase in PIC [cytosol]
precedingEvent	[Reaction:R-HSA-173115] Formation of Pre-Integration Complex (PIC) - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188934] Bushman, FD, 2006-10-30 22:19:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164514
summation	[Summation:180397] Upon completion of reverse transcription, the viral integras...

Referrals

(precedingEvent)	[Reaction:R-HSA-164522] Terminal (3' end) cleavage of viral DNA
(hasEvent)	[Pathway:R-HSA-162592] Integration of provirus

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