Reactome | Import of PIC to the Host Nucleus

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Import of PIC to the Host Nucleus Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
category	transition
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:162591] Joshi-Tope, G, 2005-03-31 22:05:41
dbId	162590
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Import of PIC to the Host Nucleus
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-162592] Integration of provirus - Homo sapiens
followingEvent	[Reaction:R-HSA-175117] 1-LTR circle formation - Homo sapiens [Reaction:R-HSA-175108] Target DNA binding - Homo sapiens [Reaction:R-HSA-175174] Association of Ku heterodimer with viral DNA ends - Homo sapiens [Reaction:R-HSA-164845] Suicidal integration leading to inverted circle formation - Homo sapiens [Reaction:R-HSA-175250] Suicidal integration leading to smaller circles of viral DNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160101] nuclear transport
input	[Complex:R-HSA-177526] IN bound to sticky 3' ends of viral DNA in PIC [cytosol]
isInDisease	true
isInferred	false
literatureReference	[Book:175927] 9780879695712 Integration Retroviruses Coffin, JM [LiteratureReference:177403] Retroviral DNA integration--mechanism and consequences
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Import of PIC to the Host Nucleus
output	[Complex:R-HSA-175416] IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm]
precedingEvent	[Reaction:R-HSA-164522] Terminal (3' end) cleavage of viral DNA - Homo sapiens [Reaction:R-HSA-180622] Vpr binds nucleoporins - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-180642] Positive regulation by 'Vpr:importin-alpha complex [cytosol]'
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188934] Bushman, FD, 2006-10-30 22:19:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-162590
summation	[Summation:175897] HIV can infect non-dividing cells, implying that the PIC mus...

Referrals

(precedingEvent)	[Reaction:R-HSA-175117] 1-LTR circle formation [Reaction:R-HSA-175108] Target DNA binding [Reaction:R-HSA-175174] Association of Ku heterodimer with viral DNA ends [Reaction:R-HSA-164845] Suicidal integration leading to inverted circle formation [Reaction:R-HSA-175250] Suicidal integration leading to smaller circles of viral DNA
(hasEvent)	[Pathway:R-HSA-162592] Integration of provirus