Integrase binds viral DNA ends

Stable Identifier
R-HSA-164514
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Integrase binds viral DNA ends
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Upon completion of reverse transcription, the viral integrase protein (IN) becomes bound to the ends of the viral DNA. This is inferred by the fact that this is the site of integrase action, and several biochemical studies have documented integrase interactions with the terminal DNA.
Literature References
PubMed ID Title Journal Year
2171144 Retroviral DNA integration directed by HIV integration protein in vitro

Bushman, FD, Fujiwara, T, Craigie, R

Science 1990
  Retroviruses

Coffin, JM, Hughes, SH, Varmus, HE

  1997
8883604 HIV cDNA integration: molecular biology and inhibitor development

Farnet, CM, Bushman, FD

AIDS 1996
  Genetic Engineering: Principles and Methods

Setlow, JK

  1998
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Gopinathrao, G  (2006-05-19)
D'Eustachio, P  (2006-05-19)
Reviewed
Bushman, FD  (2006-10-31)
Created
D'Eustachio, P  (2005-05-24)
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