Reactome | CERK phosphorylates CERA to form C1P

Schema > Reaction > Entries

CERK phosphorylates CERA to form C1P Show undefined attributes

catalystActivity	[CatalystActivity:10694282] ceramide kinase activity of CERK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10694284
displayName	CERK phosphorylates CERA to form C1P
eventOf	[Pathway:R-DME-9840309] Glycosphingolipid biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5339535] CPTP transports C1P from plasma membrane to Golgi membrane - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1638845] CERK phosphorylates CERA to form C1P - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-429807] CERA [plasma membrane]
isInDisease	false
isInferred	true
name	CERK phosphorylates CERA to form C1P Ceramide kinase (CERK) mediates the phosphorylation of ceramide
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1638840] C1P [plasma membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-DME-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Drosophila melanogaster [Reaction:R-DME-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Drosophila melanogaster [Reaction:R-DME-429683] CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1638845
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-5339535] CPTP transports C1P from plasma membrane to Golgi membrane
(hasEvent)	[Pathway:R-DME-9840309] Glycosphingolipid biosynthesis
(inferredTo)	[Reaction:R-HSA-1638845] CERK phosphorylates CERA to form C1P