Reactome | Glucagon binds to Glucagon receptor

Glucagon binds to Glucagon receptor

Stable Identifier

R-HSA-163625

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Glucagon (Thomsen J et al, 1972) is an important peptide hormone produced by the pancreas. It is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into glucose and release it into the bloodstream. The action of glucagon is thus opposite to that of insulin. Glucagon, together with glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2 (GLP-2), are peptide hormones encoded by a single common prohormone precursor, proglucagon.The glucagon receptor (Lok S et al. 1994) plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by coupling to Gs and q, which stimulate adenylyl cyclase and a phosphatidylinositol-calcium second messenger system respectively.

Literature References

PubMed ID	Title	Journal	Year
11946536	The amino acid sequence of human glucagon Sundby, F, Kristiansen, K, Brunfeldt, K, Thomsen, J	FEBS Lett	1972
15464082	Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists Gibson, RE, Dallas-Yang, Q, Candelore, MR, Shen, X, Saperstein, R, Zhang, BB, Qureshi, SA, Jiang, G, Szalkowski, D, Strowski, M, Parmee, ER, Fenyk-Melody, JE, Brady, E	Eur J Pharmacol	2004
2826231	Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma Harris, BA, Rall, T	FEBS Lett	1987
8144028	The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization Whitmore, TE, Kramer, JM, Jelinek, LJ, Grant, FJ, Lok, S, Biggs, SH, Sprecher, CA, Mathewes, S, Rosenberg, GB, Kuijper, JL	Gene	1994