Remethylation of homocysteine (HCYS) to methionine (L-Met) can also proceed by using betaine (BET) as a methyl donor, which is oxidised to dimethylglycine (DMGLY). This reaction is also part of choline catabolism, thereby providing a link to folate-dependent, one-carbon metabolism (Li et al. 2008).
Weinshilboum, RM, Eckloff, BW, Feng, Q, Li, F, Moon, I, Pelleymounter, LL, Schaid, DJ, Lee, C, Wang, S, Yee, V, Wieben, ED
betaine-homocysteine S-methyltransferase activity of BHMT:Zn2+ tetramer [cytosol]
© 2022 Reactome