Cysteine is degraded to serine and H2S

Stable Identifier
R-HSA-1614614
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

Literature References
PubMed ID Title Journal Year
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Zhu, W, Chiku, T, Padovani, D, Banerjee, R, Singh, S, Vitvitsky, V

J Biol Chem 2009
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Marinkovic, S, Huber, R, Steegborn, C, Sondermann, P, Wahl, MC, Clausen, T, Worbs, M, Jacob, U

J Biol Chem 1999
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Catalyst Activity

L-cysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]

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