Reactome | Recruitment TBK1 to dsDNA:ZBP1 followed by its activation

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Recruitment TBK1 to dsDNA:ZBP1 followed by its activation Show undefined attributes

authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1606339] Shamovsky, V, 2011-09-21
dbId	1606324
displayName	Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
edited	[InstanceEdit:2134527] Shamovsky, V, 2012-02-23
eventOf	[Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN - Homo sapiens
followingEvent	[Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - Homo sapiens
inferredFrom	[Reaction:R-MMU-1810473] Recruitment Tbk1 to dsDNA:Dai followed by its activation - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1591233] dsDNA:ZBP1 [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-166267] TBK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1591232] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1606333] dsDNA:ZBP1:pS-172-TBK1 [cytosol]
precedingEvent	[Reaction:R-HSA-1591234] ZBP1 binds cytosolic DNA - Homo sapiens
relatedSpecies	[Species:8982084] Human alphaherpesvirus 2 [Species:2671791] Human cytomegalovirus
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1606324
summation	[Summation:1810471] ZBP1 (DAI) dimer formation enables recruitment of TBK1 and I...
updateTrackers	[UpdateTracker:9787371] Update Tracker - [Reaction:1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation - v45:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787371] Update Tracker - [Reaction:1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation - v45:[modifyText]
(hasEvent)	[Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN
(precedingEvent)	[NegativePrecedingEvent:9764715] Drug molecule: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation [NegativePrecedingEvent:9764703] Negative relationship: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation [Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1
(inferredTo)	[Reaction:R-MMU-1810473] Recruitment Tbk1 to dsDNA:Dai followed by its activation

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