Reactome | Recruitment Tbk1 to dsDNA:Dai followed by its activation

Schema > Reaction > Entries

authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1810475] Shamovsky, V, 2011-10-25
dbId	1810473
displayName	Recruitment Tbk1 to dsDNA:Dai followed by its activation
edited	[InstanceEdit:2134524] Shamovsky, V, 2012-02-23
followingEvent	[Reaction:R-MMU-1810458] Recruitment of Irf3 to activated Dai:Tbk1 - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-1810469] dsDNA:Dai [cytosol] 2 × [EntityWithAccessionedSequence:R-MMU-1810477] Tbk1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1591232] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment Tbk1 to dsDNA:Dai followed by its activation
orthologousEvent	[Reaction:R-HSA-1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation - Homo sapiens
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-1810461] dsDNA:Dai:pS-172-Tbk1 [cytosol]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1810473
summation	[Summation:1810463] In murine L929 cells Dai dimer formation enables recruitment...

(precedingEvent)

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