Reactome | dsDNA:ZBP1:pS-172-TBK1 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] - Homo sapiens [Complex:R-HSA-9679814] TBK1:amlexanox [cytosol] - Homo sapiens [Complex:R-HSA-3249384] NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9679819] TBK1 binds amlexanox - Homo sapiens [Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - Homo sapiens [Reaction:R-HSA-8948703] NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 - Homo sapiens
created	[InstanceEdit:1606339] Shamovsky, V, 2011-09-21
dbId	1606333
disease	[Disease:3134792] bacterial infectious disease [Disease:3134794] viral infectious disease
displayName	dsDNA:ZBP1:pS-172-TBK1 [cytosol]
hasComponent	[Complex:R-HSA-1591233] dsDNA:ZBP1 [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-168379] p-S172-TBK1 [cytosol]
inDisease	true
isChimeric	false
modified	[InstanceEdit:9014360] Shamovsky, Veronica, 2017-07-28
name	dsDNA:ZBP1:pS-172-TBK1
producedByEvent	[Reaction:R-HSA-1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation - Homo sapiens [Reaction:R-HSA-1606327] Phosphorylation and release of IRF3 - Homo sapiens
relatedSpecies	[Species:8982084] Human alphaherpesvirus 2 [Species:2671791] Human cytomegalovirus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1606333

(input)	[Reaction:R-HSA-8948703] NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 [Reaction:R-HSA-9679819] TBK1 binds amlexanox [Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1
(output)	[Reaction:R-HSA-1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation [Reaction:R-HSA-1606327] Phosphorylation and release of IRF3
(hasComponent)	[Complex:R-HSA-9679814] TBK1:amlexanox [cytosol] [Complex:R-HSA-3249384] NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] [Complex:R-HSA-1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol]